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The latest press... Published results from pre-clinical studies basic highlights-not full article. "The Antigen Express studies demonstrate that mice immunized with an Ii-Key/HPV16 E7 hybrid show increased killing of cells expressing an HPV-specific antigen, but not control cells lacking the antigen. Consistent with the predicted mechanism of action of the vaccine, HPV-specific activation of CD4+ T helper cells was observed in immunized mice. The first author of the study, Dr. Minzhen Xu, is Vice-President of Biology at Antigen Express. The current studies demonstrate an additional application of the Ii-Key technology platform being developed at Antigen Express. Currently, another peptide designed with this technology is the subject of three clinical trials: a Phase II trial in breast cancer patients, a Phase I trial in prostate cancer patients, and a separate Phase I trial in breast or ovarian cancer patients wherein it is being tested in combination with another peptide vaccine. That immunotherapeutic vaccine, AE37, couples Ii-Key with a fragment of the HER2 protein, which is expressed in a variety of cancers and is associated with worse prognosis. While prophylactic vaccines against HPV-induced cervical cancer are available, those vaccines do not benefit patients once cancer has arisen. The difference is that Ii-Key/HPV hybrid vaccines help to induce a cellular immune response, which is necessary for killing cancer cells. In addition to developing immunotherapeutic vaccines for cancer, Antigen Express is also developing vaccines for infectious diseases, including the potentially pandemic H5N1 virus as well as the recent H1N1 pandemic virus. The fact that Antigen Express vaccines are manufactured by an entirely synthetic process, enabling rapid production of large amounts, makes them uniquely suited as a vaccine for pandemic or potentially pandemic viruses, given the supply limitations of more traditional vaccines. About Generex Biotechnology Corporation " ref: http://www.marketwatch.com/story/gen...ervical-cancer
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CORRECTED - CORRECTED-BRIEF-Generex drug approved for investigational treatm | Markets | Markets News | Reuters
"(Corrects headline to show that the Generex drug was approved as an investigational treatment for patients with life-threatening conditions, and has not received marketing approval from the FDA) Sept 10 (Reuters) - Generex Biotechnology Corp (GNBT.O): * Announces FDA approval of use of company's flagship buccal insulin product, Generex oral-Lyn, under the FDA's treatment investigational new drug (IND) program * Says FDA granted approval for treatment use of Generex Oral-Lyn under the treatment IND program" is moving as of today on this news--it was briefly over 1 dollar this morning. |
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