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Old 02-19-2019, 08:47 AM   Nav to Top  #1
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Default (SEEL) MC $21 M --Cash $18 M--O/S 6.2 M-- 2 potential Blockbuster in P3

SEEL =Market Cap $21 M// Cash $18 M// Shares Out 6.2 M //Very attractive Pipeline including 2 potential Blockbuster in Phase 3 (Parkinson Disease & PTSD) //UNDISCOVERED Stock with significant Upside Potential could be the next 10 bagger gem .GL

Seelos Therapeutics (SEEL)

Market Cap $22.5 Million
Cash $18 Million
Price $3.67

Shares Out 32 Million

Seelos Therapeutics Gains Nasdaq Listing via Reverse Merger

The next Sage? Shkreli partner Ligand puts together another sweet startup package deal for Seelos

SLS-002 is intranasal racemic ketamine with two investigational new drug applications ("INDs"), for the treatment of suicidality in post-traumatic stress disorder ("PTSD"), and in major depressive disorder. SLS-002 was originally derived from a Javelin Pharmaceuticals, Inc./Hospira, Inc. program with 16 clinical studies involving approximately 500 subjects. SLS-002 addresses an unmet need for an efficacious drug to treat suicidality in the U.S. Traditionally, anti-depressants have been used in this setting but many of the existing treatments are known to contribute to an increased risk of suicidal thoughts in some circumstances. The clinical development program for SLS-002 includes two parallel healthy volunteer studies (Phase I), expected to be rapidly followed by pivotal registration studies after an end-of-phase II meeting with the FDA. We believe there is a large opportunity in the U.S. and European markets for products in this space. Based on information gathered from the databases of the Agency for Healthcare Research and Quality, there were more than 500,000 visits to emergency rooms for suicide attempts in 2013 in the U.S. alone. Furthermore, the 12-month prevalence of attempted suicide in individuals with PTSD is approximately 400,000 in the U.S. based on the published literature. Experimental studies suggest ketamine to be a rapid, effective treatment for refractory depression and suicidality. We plan to commence a Phase III clinical trial of SLS-002 in patients with suicidality in 2019.

SLS-006 is a true partial dopamine agonist, originally developed by Wyeth Pharmaceuticals, Inc., with previous clinical studies on 340 subjects in various Phase I and Phase II studies. It is a potent D2/D3 agonist/antagonist that has shown promising efficacy with statistical significance in Phase II studies in early stage Parkinson's disease patients and an attractive safety profile. Moreover, it has also shown synergistic effect with reduced doses of L-DOPA. We are planning to advance the product candidate into late stage trials as a monotherapy in early stage Parkinson's disease patients and as an adjunctive therapy with reduced doses of L-DOPA in late stage Parkinson's disease patients after consultation with and approval from the FDA and the EMA. We believe that this Phase III-ready candidate is well-positioned to advance in development with a goal of providing relief to an estimated 1.5 million Parkinson's disease patients worldwide. We plan to commence a Phase III clinical trial of SLS-006 as an adjunctive therapy with reduced doses of L-DOPA in patients with late-stage Parkinson's disease in 2019.

Additionally, we are developing several preclinical programs, most of which have well-defined mechanisms of action, including:

SLS-008 , an orally available antagonist for Chemoattractant Receptor-homologous molecule expressed on TH2 cells ("CRTh2"), targeted at chronic inflammation in asthma and orphan indications such as pediatric esophagitis. We have a "family" of compounds under its SLS-008 program. We intend to file an IND in 2019 in an undisclosed pediatric orphan indication where there is a high unmet need for an effective oral therapy.

SLS-010 , an oral histamine H3A receptor antagonist that shows promising activity in narcolepsy and related disorders.

SLS-012 , an injectable therapy for post-operative pain management.

We intend to become a leading biopharmaceutical company focused on neurological and psychiatric disorders, including orphan indications. Our business strategy includes:

Advancing SLS-002 in suicidality in PTSD and in major depressive disorder;

Filing an IND for SLS-008 in pediatric esophagitis and another undisclosed indication;

Forming strategic collaborations in the European Union and Asian markets; and

Acquiring synergistic assets in the central nervous system therapy space through licensing and partnerships.
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