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Alnylam (ALNY) Q2 Loss Narrower than Expected, Sales Miss

Zacks

Alnylam Pharmaceuticals, Inc. ALNY reported a loss of $1.34 per share in the second quarter of 2017, narrower than the Zacks Consensus Estimate of a loss of $1.45 but wider than the year-ago loss of $1.05.

Alnylam Pharmaceuticals, Inc. Price and EPS Surprise


Alnylam Pharmaceuticals, Inc. Price and EPS Surprise | Alnylam Pharmaceuticals, Inc. Quote

Quarterly revenues rose 82.9% to 15.9 million. However, revenues missed the Zacks Consensus Estimate of $22.2 million. Revenues in the quarter included $14.4 million earned under the company's collaboration agreement with Sanofi’s SNY subsidiary, Genzyme, as well as $1.5 million from the company’s alliance with The Medicines Company MDCO.

Alnylam’s stock has increased 115.1% year to date, while the Zacks classified industry gained 8.7%.

Quarter in Detail

Research and development expenses fell 8.9% from the year-ago period to $90.7 million. However, general and administrative expenses more than doubled to $45.8 million.

Guidance

Alnylam expects its cash, cash equivalents and marketable securities (including restricted investments) to be greater than $1.0 billion at the end of the year.

Pipeline Updates

The company is making steady progress with the pipeline. The company is evaluating patisiran, an investigational RNAi therapeutic for the treatment of patients with hereditary ATTR (hATTR) amyloidosis with polyneuropathy. Top-line data from the phase III study, APOLLO is expected shortly. Assuming positive data from the study, findings will support the company’s first NDA filing (expected by year end).

The company initiated a phase III study, ATLAS, to evaluate the safety and efficacy of fitusiran in patients with hemophilia A and B with or without inhibitors. The company expects to initiate a phase III study by yearend for givosiran in acute hepatic porphyrias in collaboration with Medicines Company.

The company also advanced givosiran, an investigational RNAi therapeutic for the treatment of acute hepatic porphyrias. The company presented positive new data at the 2017 International Congress on Porphyrins and Porphyriasfrom the ongoing randomized, double-blind, placebo-controlled phase I study in recurrent attack porphyria patients, as well as positive initial results from the ongoing phase I OLE study. The FDA granted Breakthrough Therapy designation to the candidate from the FDA to givosiran for the prophylaxis of attacks in patients with acute hepatic porphyria.

Our Take

Alnylam’s second-quarter results were mixed with the company reporting a narrower-than-expected loss but sales missed estimates. With several pipeline-related events lined up for the upcoming quarters, we expect investor focus to remain on further updates by the company.

Zacks Rank & Key Picks

Alnylam carries a Zacks Rank #3 (Hold). A better-ranked stock in the healthcare sector is Gilead Sciences. Inc. GILD which currently carries a Zacks Rank #2 (Buy). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.

Gilead’s earnings per share estimates increased from $7.98 to $8.21 for 2017 and from $7.18 to $7.33 for 2018, over the last seven days following strong results in the second quarter. The company delivered positive earnings surprises in three of the trailing four quarters, with an average beat of 8.18%. The share price of the company has increased 18.9% year to date.

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