Jazz Pharmaceuticals Public Limited Company JAZZ announced that its phase III study, evaluating JZP-110 has completed patient enrollment. The study is evaluating JZP-110 for the treatment of excessive sleepiness (ES) associated with narcolepsy.
The phase III narcolepsy study is a double-blind, placebo-controlled, multiple-center study, which enrolled 240 patients. The Maintenance of Wakefulness Test and the Epworth Sleepiness Scale were the co-primary endpoints. These measure the patient’s ability to stay awake and the severity of ES in them.
JZP-110 is also being evaluated in two phase III studies for the treatment of ES associated with obstructive sleep apnea (OSA).
The company expects to report positive results from the OSA studies in the first quarter of 2017 and from the narcolepsy study in the second quarter of 2017. Positive data from these studies would allow the company to file for approval in late 2017.
JZP-110, which enjoys Orphan Drug designation in the U.S. for narcolepsy, complements Jazz’s existing sleep disorder portfolio. According to the company, there is significant unmet need in narcolepsy and OSA with about 175–300K patients having an inadequate response to current wake-promoting therapies. More than 50% of patients fail one or more stimulants or wake-promoting agents. Data generated on JZP-110 looks good so far.
In Sep 2016, Jazz announced the completion of patient enrollment in the two OSA phase III studies.
Jazz is a Zacks Rank #3 (Hold) stock. The company’s share price is down almost 1.5%, while the medical drugs market is up at 8.74% in the last one month. Some better-ranked stocks in the healthcare sector include Heska Corporation HSKA, Arbutus Biopharma Corporation ABUS and Anika Therapeutics Inc. ANIK. Heska sports a Zacks Rank #1 (Strong Buy) while Arbutus and Anika carries a Zacks Rank #2 (Buy). You can see the complete list of today’s Zacks #1 Rank stocks here.
Heska’s earnings estimates increased from $1.13 per share to $1.35 for 2016 and from $1.38 per share to $1.53 for 2017, over the last 60 days. The company posted positive surprises in each of the four trailing quarters, with an average beat of 301.64%. Share price has increased 69.60% year to date for the company.
Arbutus’ loss estimates narrowed from $2.15 to $1.74 per share for 2016 and from $1.96 to $1.51 per share for 2017 over the last 60 days. The company posted positive surprises in three of the trailing four quarters, with an average beat of 59.31%.
Anika’s earnings estimates increased from $1.96 per share to $2.06 for 2016 and from $2.03 per share to $2.09 for 2017, over the last 60 days. The company posted positive surprises in each of the four trailing quarters, with an average beat of 33.14%.
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